In diseases including celiacs and inflammatory bowel disease, the inflammatory cells in the intestinal mucosa mount an immune response to antigens in the ingested food. In a recent study in Nature, DePaolo and colleagues have found a new enemy in those suffering from these diseases. The cytokine, IL-15, an activator of the immune response, is elevated in patients. This leads to an increase in T lymphocyte development, specifically Th1 cell development, and an produces an inflammatory response leading to the digestive complications found in celiacs and inflammatory bowel disease. These findings also suggest that anti-IL15 therapy may be an effective way to prevent these diseases or restore systems back to normal.
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n3 science communications
1 comment:
Fantastic!
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